Sugi Predict

Sugi Predict / Compounds / SCHEMBL3942289

SCHEMBL3942289

SCHEMBL3942289

CCOC(=O)c1ccc2c(c1)NC(=O)C2=C(Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccc2c(c1)OCCO2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AAK1 Q2M2I8 1/20 0.46
▸ MAPT P10636 6/20 0.43
▸ LMNA P02545 3/20 0.43
▸ MEN1 O00255 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ USP2 O75604 1/20 0.43
▸ GAA P10253 2/20 0.42
▸ PDGFRB P09619 2/20 0.40
▸ FGFR1 P11362 2/20 0.40
▸ PDGFRA P16234 2/20 0.40
▸ FLT1 P17948 2/20 0.40
▸ FGFR2 P21802 2/20 0.40
▸ FGFR4 P22455 2/20 0.40
▸ FGFR3 P22607 2/20 0.40
▸ FLT4 P35916 2/20 0.40
▸ KDR P35968 2/20 0.40
▸ ABL1 P00519 1/20 0.40
▸ NTRK1 P04629 1/20 0.40
▸ CSF1R P07333 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3942286 1.00 AAK1 (0.46) AAK1MAPTLMNAMEN1KMT2A
SCHEMBL3931942 0.96 AAK1 (0.46) AAK1MAPTLMNAMEN1KMT2A
SCHEMBL3931946 0.96 AAK1 (0.46) AAK1MAPTLMNAMEN1KMT2A
SCHEMBL3933537 0.95 AAK1 (0.51) AAK1MAPTLMNAMEN1KMT2A
SCHEMBL3933534 0.95 AAK1 (0.51) AAK1MAPTLMNAMEN1KMT2A
SCHEMBL5858167 0.89 AAK1 (0.44) AAK1MAPTLMNAMEN1KMT2A
SCHEMBL5858175 0.89 AAK1 (0.45) AAK1MAPTLMNAMEN1KMT2A
SCHEMBL480662 0.89 AAK1 (0.52) AAK1LMNAMAPK1PDGFRBFGFR1
SCHEMBL480663 0.89 AAK1 (0.52) AAK1LMNAMAPK1PDGFRBFGFR1
SCHEMBL3943218 0.88 AAK1 (0.49) AAK1MAPTLMNAMAPK1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551830-B1 HETEROCYCLICALLY SUBSTITUTED INDOLINONES AND THEIR USE AS RECEPTOR TYROSINE KINASE INHIBATORS BOEHRINGER INGELHEIM PHARMA (DE) 2009-04-08 — — EP disclosed
US-7148249-B2 Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2006-12-12 — — US disclosed
EP-1551830-A2 HETEROCYCLICALLY SUBSTITUTED INDOLINONES AND THEIR USE AS RECEPTOR TYROSINE KINASE INHIBATORS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2005-07-13 — — EP disclosed
US-20050054710-A1 Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2005-03-10 — — US disclosed
WO-2004026829-A2 HETEROCYCLICALLY SUBSTITUTED INDOLINONES AND THEIR USE AS RECEPTOR TYROSINE KINASE INHIBITORS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-04-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050054710-A1 Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments CDK1, CDK2, CDK3 AAK1 1459/4885MAPT 1798/4885LMNA 1567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.