Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 6/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3938639 | 0.89 | TSHR (0.41) | KCNA5P2RX7TSHRKCNH2HTT | |
| SCHEMBL3758325 | 0.86 | KCNA5 (0.61) | KCNA5P2RX7TSHRKCNH2HTT | |
| SCHEMBL3750444 | 0.81 | KCNA5 (0.48) | KCNA5P2RX7TSHRKCNH2HTT | |
| SCHEMBL3949423 | 0.79 | KCNA5 (0.57) | KCNA5TSHRKCNH2HTTSCN9A | |
| SCHEMBL3754228 | 0.76 | KCNA5 (0.77) | KCNA5P2RX7KCNH2PTGESBRS3 | |
| SCHEMBL3745315 | 0.76 | KCNA5 (0.77) | KCNA5P2RX7KCNH2PTGESBRS3 | |
| SCHEMBL3749096 | 0.74 | KCNA5 (0.55) | KCNA5P2RX7TSHRKCNH2HTT | |
| SCHEMBL3751379 | 0.73 | KCNA5 (0.54) | KCNA5P2RX7TSHRKCNH2HTT | |
| SCHEMBL3754303 | 0.72 | KCNA5 (0.54) | KCNA5P2RX7TSHRKCNH2HTT | |
| SCHEMBL3751700 | 0.72 | KCNA5 (0.53) | KCNA5P2RX7TSHRKCNH2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | claimed |