SCHEMBL3942891

SCHEMBL3942891

O=C(O)Oc1ccc2ncncc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 7/20 0.61
ALDH1A1 P00352 2/20 0.47
F2 P00734 1/20 0.47
GLA P06280 1/20 0.47
HPGD P15428 1/20 0.47
PIK3CD O00329 1/20 0.42
PIK3CA P42336 1/20 0.42
AR P10275 1/20 0.41
FGFR4 P22455 1/20 0.40
NAMPT P43490 1/20 0.39
ABL1 P00519 2/20 0.36
SRC P12931 2/20 0.36
PDE3B Q13370 1/20 0.36
PDE3A Q14432 1/20 0.36
TDO2 P48775 1/20 0.36
MEN1 O00255 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
BAZ1A Q9NRL2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL535665 0.89 EGFR (0.64) EGFRALDH1A1F2GLAHPGD
SCHEMBL27881436 0.88 EGFR (0.62) EGFRALDH1A1F2GLAHPGD
Hydrochloric Acid SCHEMBL30406782 0.88 EGFR (0.62) EGFRALDH1A1F2GLAHPGD
Hydrochloric Acid SCHEMBL27748921 0.88 EGFR (0.62) EGFRALDH1A1F2GLAHPGD
SCHEMBL7513856 0.87 EGFR (0.61) EGFRALDH1A1F2GLAHPGD
SCHEMBL27651503 0.84 KMT2A (0.59) EGFRALDH1A1PIK3CDPIK3CANAMPT
SCHEMBL30648200 0.84 KMT2A (0.59) EGFRALDH1A1PIK3CDPIK3CANAMPT
SCHEMBL27685719 0.83 EGFR (0.56) EGFRALDH1A1F2GLAHPGD
SCHEMBL13480994 0.82 EGFR (0.59) EGFRALDH1A1F2GLAHPGD
SCHEMBL5144896 0.82 EGFR (0.55) EGFRALDH1A1F2GLAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551830-B1 HETEROCYCLICALLY SUBSTITUTED INDOLINONES AND THEIR USE AS RECEPTOR TYROSINE KINASE INHIBATORS BOEHRINGER INGELHEIM PHARMA (DE) 2009-04-08 EP disclosed
EP-1551830-A2 HETEROCYCLICALLY SUBSTITUTED INDOLINONES AND THEIR USE AS RECEPTOR TYROSINE KINASE INHIBATORS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2005-07-13 EP disclosed
WO-2004026829-A2 HETEROCYCLICALLY SUBSTITUTED INDOLINONES AND THEIR USE AS RECEPTOR TYROSINE KINASE INHIBITORS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-04-01 WO disclosed
EP-0094080-B1 PYRIDO(2,1-B)QUINAZOLINE DERIVATIVES F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1987-09-09 EP disclosed