Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 14/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3948928 | 0.78 | CCR1 (0.48) | CCR1KCNH2 | |
| SCHEMBL3943636 | 0.78 | CCR1 (0.59) | CCR1KCNH2 | |
| SCHEMBL2159729 | 0.77 | CCR1 (0.67) | CCR1KCNH2 | |
| SCHEMBL3940825 | 0.76 | CCR1 (0.46) | CCR1KCNH2DRD2 | |
| SCHEMBL2159204 | 0.76 | CCR1 (0.84) | CCR1KCNH2 | |
| SCHEMBL10291656 | 0.75 | CCR1 (0.84) | CCR1KCNH2 | |
| SCHEMBL2159263 | 0.75 | CCR1 (0.85) | CCR1KCNH2 | |
| SCHEMBL2160096 | 0.75 | CCR1 (0.85) | CCR1KCNH2 | |
| SCHEMBL2158985 | 0.74 | CCR1 (0.84) | CCR1KCNH2 | |
| SCHEMBL13776456 | 0.71 | HPGD (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049486-A2 | PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007092681-A2 | PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-16 | — | — | WO | disclosed |