SCHEMBL3943610

SCHEMBL3943610

O[C@@H]1[C@@H](O)[C@H](c2ccc(Cl)c(Cc3ccc(-c4ccccc4)s3)c2)O[C@H](CF)[C@H]1O

nearest known ligand 0.67

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 20/20 0.67
SLC5A1 P13866 2/20 0.66
ABCB11 O95342 1/20 0.56
ADORA3 P0DMS8 1/20 0.56
SLC6A4 P31645 1/20 0.56
SLC6A3 Q01959 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14302395 1.00 SLC5A2 (0.67) SLC5A2SLC5A1ABCB11ADORA3SLC6A4
SCHEMBL14278452 1.00 SLC5A2 (0.67) SLC5A2SLC5A1ABCB11ADORA3SLC6A4
SCHEMBL14302213 0.91 SLC5A2 (0.80) SLC5A2SLC5A1ABCB11ADORA3SLC6A4
SCHEMBL1585185 0.91 SLC5A2 (0.80) SLC5A2SLC5A1ABCB11ADORA3SLC6A4
SCHEMBL14278451 0.91 SLC5A2 (0.68) SLC5A2SLC5A1ABCB11ADORA3SLC6A4
SCHEMBL154723 0.91 SLC5A2 (0.80) SLC5A2SLC5A1ABCB11ADORA3SLC6A4
SCHEMBL14302420 0.86 SLC5A2 (0.68) SLC5A2SLC5A1ABCB11ADORA3SLC6A4
SCHEMBL3936832 0.86 SLC5A2 (0.68) SLC5A2SLC5A1ABCB11ADORA3SLC6A4
SCHEMBL14278453 0.86 SLC5A2 (0.68) SLC5A2SLC5A1ABCB11ADORA3SLC6A4
SCHEMBL14310972 0.86 SLC5A2 (0.68) SLC5A2SLC5A1ABCB11ADORA3SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080027014-A1 Novel SGLT inhibitors TANABE SEIYAKU CO., LTD. 2008-01-31 US claimed
EP-2046346-A1 NOVEL SGLT INHIBITORS Mitsubishi Tanabe Pharma Corporation (JP) 2009-04-15 EP disclosed
US-20080027014-A1 Novel SGLT inhibitors TANABE SEIYAKU CO., LTD. 2008-01-31 US disclosed
WO-2008013321-A1 NOVEL SGLT INHIBITORS MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-01-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080027014-A1 Novel SGLT inhibitors SLC5A1, SLC5A2, SLC10A1 SLC5A2 2/4885SLC5A1 1/4885ABCB11 116/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.