Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943975 | 1.00 | MAPT (0.35) | MAPTKMT2AMAPK1L3MBTL1THRA | |
| SCHEMBL3937768 | 0.88 | MAPT (0.37) | MAPTKMT2AMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL3937769 | 0.88 | MAPT (0.37) | MAPTKMT2AMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL4488274 | 0.88 | MAPT (0.37) | MAPTKMT2AMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL4494848 | 0.85 | MAPT (0.38) | MAPTKMT2AMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL3935261 | 0.85 | MAPT (0.38) | MAPTKMT2AMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL3935258 | 0.85 | MAPT (0.38) | MAPTKMT2AMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL4490205 | 0.84 | MAPT (0.36) | MAPTKMT2AMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL3935326 | 0.84 | MAPT (0.36) | MAPTKMT2AMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL3935329 | 0.84 | MAPT (0.36) | MAPTKMT2AMAPK1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551830-B1 | HETEROCYCLICALLY SUBSTITUTED INDOLINONES AND THEIR USE AS RECEPTOR TYROSINE KINASE INHIBATORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-04-08 | — | — | EP | disclosed |