Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.56 |
| ▸ | RAF1 | P04049 | 14/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3936862 | 0.89 | BRAF (0.57) | BRAFRAF1CYP2C9 | |
| SCHEMBL26075758 | 0.84 | RAF1 (0.58) | BRAFRAF1 | |
| SCHEMBL29877984 | 0.84 | RAF1 (0.58) | BRAFRAF1 | |
| SCHEMBL3939108 | 0.83 | BRAF (0.78) | BRAFCYP2C9 | |
| SCHEMBL3941881 | 0.83 | BRAF (0.71) | BRAFCYP2C9 | |
| SCHEMBL3933224 | 0.82 | BRAF (0.62) | BRAFRAF1CYP2C9 | |
| SCHEMBL26075590 | 0.80 | RAF1 (0.55) | BRAFRAF1 | |
| SCHEMBL29877572 | 0.80 | MAPT (0.58) | BRAFRAF1 | |
| SCHEMBL3934840 | 0.80 | BRAF (0.78) | BRAFRAF1CYP2C9 | |
| SCHEMBL17523461 | 0.79 | RAF1 (0.51) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |