Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 1.00 |
| ▸ | CDK7 | P50613 | 18/20 | 1.00 |
| ▸ | CDK4 | P11802 | 17/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 17/20 | 1.00 |
| ▸ | CCNH | P51946 | 17/20 | 1.00 |
| ▸ | CDK1 | P06493 | 16/20 | 1.00 |
| ▸ | CCND1 | P24385 | 15/20 | 1.00 |
| ▸ | CCNB1 | P14635 | 14/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 12/20 | 1.00 |
| ▸ | CDK9 | P50750 | 6/20 | 0.87 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.84 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.84 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.84 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1379184 | 1.00 | CDK2 (1.00) | CDK2CDK7CDK4CCNE1CCNH | |
| SCHEMBL31060362 | 1.00 | CDK2 (1.00) | CDK2CDK7CDK4CCNE1CCNH | |
| SCHEMBL3855548 | 1.00 | CDK2 (1.00) | CDK2CDK7CDK4CCNE1CCNH | |
| SCHEMBL3298407 | 0.93 | CDK2 (1.00) | CDK2CDK7CDK4CCNE1CCNH | |
| SCHEMBL1376090 | 0.91 | CDK2 (1.00) | CDK2CDK7CDK4CCNE1CCNH | |
| SCHEMBL31061282 | 0.91 | CDK2 (1.00) | CDK2CDK7CDK4CCNE1CCNH | |
| SCHEMBL3858001 | 0.91 | CDK2 (1.00) | CDK2CDK7CDK4CCNE1CCNH | |
| SCHEMBL5072968 | 0.91 | CDK2 (1.00) | CDK2CDK7CDK4CCNE1CCNH | |
| SCHEMBL1378920 | 0.91 | CDK2 (1.00) | CDK2CDK7CDK4CCNE1CCNH | |
| SCHEMBL29829223 | 0.91 | CDK2 (1.00) | CDK2CDK7CDK4CCNE1CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010533-A2 | PROCESS FOR THE PREPARATION OF 2,6,9-TRISUBSTITUTED PURINES | Cyclacel Limited (GB) | 2009-01-07 | — | — | EP | claimed |
| WO-2007110649-A2 | PROCESS FOR THE PREPARATION OF 2,6,9-TRISUBSTITUTED PURINES | CYCLACEL LIMITED (GB) | 2007-10-04 | — | — | WO | claimed |
| EP-1951307-A2 | COMBINATION OF A CDK-INHIBITOR AND A HDAC-INHIBITOR | Cyclacel Limited (GB) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007054725-A2 | COMBINATION OF A CDK-INHIBITOR AND A HDAC-INHIBITOR | CYCLACEL LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |