Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942111 | 0.90 | HTT (0.46) | HTTSMN1; SMN2KMT2ALMNATSHR | |
| SCHEMBL3943049 | 0.88 | HTT (0.48) | HTTSMN1; SMN2KMT2ALMNATSHR | |
| SCHEMBL3951590 | 0.86 | FGFR1 (0.42) | HTTPKMMAPTROCK1 | |
| SCHEMBL3949567 | 0.84 | HTT (0.59) | HTTSMN1; SMN2KMT2ALMNATSHR | |
| SCHEMBL3944398 | 0.84 | HTT (0.60) | HTTSMN1; SMN2KMT2ALMNATSHR | |
| SCHEMBL3949407 | 0.83 | HTT (0.69) | HTTSMN1; SMN2KMT2ALMNATSHR | |
| SCHEMBL3946876 | 0.83 | HTT (0.66) | HTTSMN1; SMN2KMT2ALMNATSHR | |
| SCHEMBL3949251 | 0.82 | HTT (0.55) | HTTSMN1; SMN2KMT2ALMNATSHR | |
| SCHEMBL3951616 | 0.81 | HTT (0.60) | HTTSMN1; SMN2KMT2ALMNATSHR | |
| SCHEMBL3943074 | 0.80 | HTT (0.53) | HTTSMN1; SMN2KMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |