Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.66 |
| ▸ | MTOR | P42345 | 4/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.66 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PHGDH | O43175 | 1/20 | 0.59 |
| ▸ | MGLL | Q99685 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3937371 | 0.89 | EPHX2 (1.00) | EPHX2PIK3CAMTORPIK3CGL3MBTL3 | |
| SCHEMBL3937303 | 0.88 | EPHX2 (0.77) | EPHX2PIK3CAMTORPIK3CGHPGD | |
| SCHEMBL4319942 | 0.84 | EPHX2 (0.73) | EPHX2PIK3CAMTORPIK3CGL3MBTL3 | |
| SCHEMBL32568 | 0.83 | PIK3CA (0.93) | EPHX2PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL3956569 | 0.80 | EPHX2 (0.67) | EPHX2PIK3CAMTORPIK3CGHPGD | |
| SCHEMBL32299 | 0.80 | PIK3CA (1.00) | EPHX2PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL3936743 | 0.79 | MAPT (0.79) | EPHX2MAPTMGLL | |
| SCHEMBL32309 | 0.79 | PIK3CA (1.00) | EPHX2PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL24709929 | 0.77 | PIK3CA (0.85) | EPHX2PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL1430604 | 0.77 | PIK3CA (0.81) | PIK3CAMTORPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046329-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | Arete Therapeutics, INC. (US) | 2009-04-15 | — | — | EP | claimed |
| US-20080032978-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. | 2008-02-07 | — | — | US | claimed |
| WO-2008016884-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. (US) | 2008-02-07 | — | — | WO | claimed |
| EP-2046329-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | Arete Therapeutics, INC. (US) | 2009-04-15 | — | — | EP | disclosed |
| US-20080032978-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. | 2008-02-07 | — | — | US | disclosed |
| WO-2008016884-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008016884-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |
| US-20080032978-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. | 2008-02-07 | — | — | US | disclosed |
| US-20080032978-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032978-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | EPHX1, EPHX2, NCEH1 | EPHX2 2/4885PIK3CA 3062/4885MTOR 2222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.