Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7686 | 0.98 | TSHR (0.43) | TSHRTP53ALDH1A1LMNAF2 | |
| SCHEMBL1483657 | 0.98 | TSHR (0.43) | TSHRTP53ALDH1A1LMNAF2 | |
| SCHEMBL2904556 | 0.98 | TSHR (0.43) | TSHRTP53ALDH1A1LMNAF2 | |
| SCHEMBL223031 | 0.98 | TSHR (0.43) | TSHRTP53ALDH1A1LMNAF2 | |
| SCHEMBL221679 | 0.98 | TSHR (0.43) | TSHRTP53ALDH1A1LMNAF2 | |
| SCHEMBL27362899 | 0.98 | TSHR (0.43) | TSHRTP53ALDH1A1LMNAF2 | |
| Water SCHEMBL1818831 | 0.97 | TSHR (0.42) | TSHRTP53ALDH1A1LMNAF2 | |
| Water SCHEMBL789812 | 0.97 | TSHR (0.42) | TSHRTP53ALDH1A1LMNAF2 | |
| Ammonia Solution, Strong SCHEMBL11444698 | 0.97 | TSHR (0.42) | TSHRTP53ALDH1A1LMNAF2 | |
| SCHEMBL11542849 | 0.97 | TSHR (0.42) | TSHRTP53ALDH1A1LMNAF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539684-B1 | BENZENESULPHONAMIDES AND PROCESS FOR THEIR PREPARATION | RICHTER GEDEON NYRT (HU) | 2009-04-15 | — | — | EP | disclosed |
| EP-1539684-A1 | BENZENESULPHONAMIDES AND PROCESS FOR THEIR PREPARATION | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004022532-A1 | BENZENESULPHONAMIDES AND PROCESS FOR THEIR PREPARATION | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2004-03-18 | — | — | WO | disclosed |