Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 10/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.48 |
| ▸ | ESRRA | P11474 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19920869 | 0.83 | BRD4 (0.62) | BRD4MEN1KMT2AALDH1A1ESRRA | |
| SCHEMBL15263687 | 0.79 | BRD4 (0.58) | BRD4BRD9BRD7ESRRA | |
| SCHEMBL3103150 | 0.78 | BRD4 (0.72) | TP53BRD4MEN1KMT2AALDH1A1 | |
| SCHEMBL15264930 | 0.78 | BRD4 (0.56) | BRD4MEN1KMT2ACREBBPALDH1A1 | |
| SCHEMBL5293903 | 0.77 | BRD4 (0.56) | BRD4MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL31590170 | 0.77 | BRD4 (0.48) | BRD4CREBBPBRD2ESRRA | |
| SCHEMBL1383683 | 0.76 | BRD4 (0.54) | BRD4ESRRA | |
| SCHEMBL15264702 | 0.76 | BRD4 (0.55) | BRD4ESRRA | |
| SCHEMBL15279904 | 0.75 | BRD4 (0.53) | BRD4MEN1KMT2ACREBBPALDH1A1 | |
| SCHEMBL15279843 | 0.75 | BRD4 (0.53) | BRD4BRD9BRD2BRD7ESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029214-A1 | ISOQUINOLONE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2009-03-05 | — | — | WO | claimed |
| US-20090054434-A1 | ISOQUINOLONE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2009-02-26 | — | — | US | claimed |
| WO-2009029214-A1 | ISOQUINOLONE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2009-03-05 | — | — | WO | disclosed |
| US-20090054434-A1 | ISOQUINOLONE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054434-A1 | ISOQUINOLONE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | PDE5A, PDE4A, PDE4B | TP53 4539/4885BRD4 373/4885MEN1 3264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.