Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.57 |
| ▸ | HTR2C | P28335 | 13/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2350347 | 0.87 | HTR2A (0.71) | HTR2AHTR2CKCNH2 | |
| SCHEMBL3954204 | 0.86 | HTR2A (0.55) | HTR2AHTR2CKCNH2 | |
| SCHEMBL3953599 | 0.84 | HTR2A (0.75) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4037316 | 0.81 | HTR2A (0.57) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4036923 | 0.78 | HTR2A (0.73) | HTR2AHTR2CKCNH2 | |
| SCHEMBL5061706 | 0.77 | HTR2A (0.68) | HTR2AHTR2CKCNH2 | |
| SCHEMBL30343208 | 0.77 | HTR2A (0.68) | HTR2AHTR2CKCNH2 | |
| SCHEMBL3945624 | 0.77 | HTR2A (0.71) | HTR2AHTR2CKCNH2 | |
| SCHEMBL134069 | 0.76 | HTR2A (0.73) | HTR2AHTR2C | |
| SCHEMBL3952896 | 0.76 | HTR2A (0.56) | HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051978-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-04-29 | — | — | EP | claimed |
| WO-2007136875-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007136875-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |