Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 8/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24894673 | 1.00 | NR1H2 (0.35) | NR1H2ABCB1UCHL1PDE4BPARP1 | |
| SCHEMBL2387181 | 1.00 | NR1H2 (0.35) | NR1H2ABCB1UCHL1PDE4BPARP1 | |
| SCHEMBL9383410 | 1.00 | NR1H2 (0.35) | NR1H2ABCB1UCHL1PDE4BPARP1 | |
| SCHEMBL24826386 | 1.00 | NR1H2 (0.35) | NR1H2ABCB1UCHL1PDE4BPARP1 | |
| SCHEMBL12553792 | 1.00 | NR1H2 (0.35) | NR1H2ABCB1UCHL1PDE4BPARP1 | |
| SCHEMBL8759166 | 0.91 | NR1H2 (0.32) | NR1H2ABCB1PARP1 | |
| SCHEMBL8759141 | 0.91 | NR1H2 (0.32) | NR1H2ABCB1PARP1 | |
| SCHEMBL12519787 | 0.90 | NR1H2 (0.33) | NR1H2ABCB1UCHL1PARP1CHRM2 | |
| SCHEMBL1526484 | 0.90 | NR1H2 (0.35) | NR1H2ABCB1PARP1CHRM2CHRM1 | |
| SCHEMBL1526483 | 0.90 | NR1H2 (0.35) | NR1H2ABCB1PARP1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |