Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 17/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950242 | 0.91 | EGFR (0.42) | EGFRATRCDK1 | |
| SCHEMBL3948659 | 0.90 | ATR (0.42) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3946712 | 0.89 | ATR (0.50) | EGFRATRCDK1CDK2MKNK1 | |
| SCHEMBL3948852 | 0.82 | ATR (0.41) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3947093 | 0.81 | EGFR (0.43) | EGFRATRCDK1CDK2MKNK1 | |
| SCHEMBL3956922 | 0.81 | ATR (0.41) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3948208 | 0.81 | ATR (0.40) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3951611 | 0.79 | ATR (0.51) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3954987 | 0.78 | ATR (0.38) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3954127 | 0.78 | ATR (0.38) | ATRCDK1CDK2MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |