Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.56 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.47 |
| ▸ | AKT2 | P31751 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959426 | 0.95 | JAK3 (0.56) | JAK3JAK1DOT1LAKT2GSK3B | |
| SCHEMBL31706717 | 0.81 | JAK3 (0.67) | JAK3JAK1DOT1LAKT2GSK3B | |
| SCHEMBL7851091 | 0.75 | JAK3 (0.48) | JAK3JAK1DOT1LAKT2GSK3B | |
| SCHEMBL7842640 | 0.73 | JAK3 (0.50) | JAK3JAK1DOT1LAKT2GSK3B | |
| SCHEMBL7842635 | 0.73 | JAK3 (0.53) | JAK3JAK1AKT2GSK3BLCK | |
| SCHEMBL10169662 | 0.73 | JAK3 (0.67) | JAK3JAK1DOT1LAKT2GSK3B | |
| SCHEMBL20582811 | 0.73 | JAK3 (0.67) | JAK3JAK1DOT1LAKT2GSK3B | |
| SCHEMBL10170240 | 0.73 | JAK3 (0.67) | JAK3JAK1DOT1LAKT2GSK3B | |
| SCHEMBL15208683 | 0.73 | JAK3 (0.67) | JAK3JAK1DOT1LAKT2GSK3B | |
| SCHEMBL10169663 | 0.73 | JAK3 (0.67) | JAK3JAK1DOT1LAKT2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569569-B2 | Pyrrolo[2,3-d]pyrimidine compounds | PFIZER INC. (US) | 2009-08-04 | — | — | US | disclosed |
| EP-1087971-B1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PROD INC (US) | 2004-07-07 | — | — | EP | disclosed |
| US-6635762-B1 | Protein tyrosine kinase or Janus Kinase 3 inhibitors; immunosuppressants | PFIZER INC. | 2003-10-21 | — | — | US | disclosed |
| EP-1087971-A1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065909-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-12-23 | — | — | WO | disclosed |