Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ezutromid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTRN known ✓ | P46939 | 11/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.84 |
| ▸ | AHR | P35869 | 1/20 | 0.84 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.84 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CETP | P11597 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ezutromid SCHEMBL31080435 | 0.92 | UTRN (1.00) | UTRNCYP1A2AHRHDAC6PTPN2 | |
| Ezutromid SCHEMBL732212 | 0.92 | UTRN (1.00) | UTRNCYP1A2AHRHDAC6PTPN2 | |
| Ezutromid SCHEMBL29376738 | 0.92 | UTRN (1.00) | UTRNCYP1A2AHRHDAC6PTPN2 | |
| Ezutromid SCHEMBL30791155 | 0.92 | UTRN (1.00) | UTRNCYP1A2AHRHDAC6PTPN2 | |
| SCHEMBL3944431 | 0.84 | UTRN (0.77) | UTRNCYP1A2AHRHDAC6PTPN2 | |
| SCHEMBL3947253 | 0.84 | UTRN (0.77) | UTRNCYP1A2AHRHDAC6PTPN2 | |
| SCHEMBL2245091 | 0.80 | UTRN (0.78) | UTRNCYP1A2AHRHDAC6PTPN2 | |
| SCHEMBL2242906 | 0.80 | UTRN (0.78) | UTRNCYP1A2AHRHDAC6PTPN2 | |
| SCHEMBL2245790 | 0.79 | UTRN (0.77) | UTRNCYP1A2AHRHDAC6PTPN2 | |
| SCHEMBL4037442 | 0.79 | UTRN (0.77) | UTRNCYP1A2AHRHDAC6MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009021750-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2009-02-19 | — | — | WO | disclosed |