SCHEMBL3955030

CN(C)CCC(CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCC(NC(=O)c4ccccc4-c4ccc(Cl)cc4)CC3)cc2)cc1[N+](=O)[O-]

nearest known ligand 0.80

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	BCL2L1	Q07817	20/20	0.80

▸	BCL2	P10415	12/20	0.80

▸	BCL2L2	Q92843	2/20	0.77

▸	MDM4	O15151	1/20	0.77

▸	BCL2L11	O43521	1/20	0.77

▸	TP53	P04637	1/20	0.77

▸	BID	P55957	1/20	0.77

▸	BAX	Q07812	1/20	0.77

▸	MCL1	Q07820	1/20	0.77

▸	ASPH	Q12797	1/20	0.77

▸	BECN1	Q14457	1/20	0.77

▸	BAK1	Q16611	1/20	0.77

▸	BAD	Q92934	1/20	0.77

▸	BBC3	Q9BXH1	1/20	0.77

▸	ALB	P02768	1/20	0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3955025	1.00	BCL2L1 (0.80)	BCL2L1BCL2BCL2L2MDM4BCL2L11
SCHEMBL13906606	1.00	BCL2L1 (0.80)	BCL2L1BCL2BCL2L2MDM4BCL2L11
SCHEMBL19425643	0.92	BCL2L1 (0.68)	BCL2L1BCL2BCL2L2MDM4BCL2L11
SCHEMBL3962947	0.91	BCL2L1 (0.83)	BCL2L1BCL2BCL2L2MDM4BCL2L11
SCHEMBL13906613	0.91	BCL2L1 (0.83)	BCL2L1BCL2BCL2L2MDM4BCL2L11
SCHEMBL3962955	0.91	BCL2L1 (0.83)	BCL2L1BCL2BCL2L2MDM4BCL2L11
SCHEMBL13906747	0.90	BCL2L1 (0.74)	BCL2L1BCL2BCL2L2ALB
SCHEMBL1540286	0.90	BCL2L1 (0.84)	BCL2L1BCL2BCL2L2MDM4BCL2L11
SCHEMBL3954995	0.90	BCL2L1 (0.74)	BCL2L1BCL2BCL2L2ALB
SCHEMBL3954990	0.90	BCL2L1 (0.74)	BCL2L1BCL2BCL2L2ALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009036035-A1	BCL-2 INHIBITORS	CURIS, INC. (US)	2009-03-19	—	—	WO	disclosed