Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.61 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.61 |
| ▸ | RAF1 | P04049 | 4/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.42 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL396895 | 0.97 | NTRK1 (0.66) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL394406 | 0.97 | NTRK2 (0.59) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL396341 | 0.95 | NTRK1 (0.63) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL398007 | 0.91 | NTRK1 (0.60) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL396192 | 0.88 | NTRK1 (0.61) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL395945 | 0.86 | NTRK1 (0.51) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL396230 | 0.86 | NTRK1 (0.56) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL394525 | 0.85 | FLT3 (0.51) | NTRK1AURKANTRK3CSF1R | |
| SCHEMBL397637 | 0.85 | NTRK2 (0.58) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL4124627 | 0.83 | NTRK1 (0.71) | NTRK1NTRK2RAF1AURKASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | claimed |
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | disclosed |