Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.62 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6753744 | 0.89 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL3956750 | 0.86 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL734503 | 0.82 | PIK3CG (0.49) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL733167 | 0.82 | PIK3CD (0.86) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL733233 | 0.82 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL733123 | 0.81 | PIK3CD (0.88) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL733097 | 0.81 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL733237 | 0.81 | PIK3CG (0.51) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL734208 | 0.80 | PIK3CD (0.88) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL360745 | 0.79 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018385-B1 | THIAZOLYL-DIHYDROQUINAZOLINES | BOEHRINGER INGELHEIM INT (DE) | 2013-05-15 | — | — | EP | disclosed |
| EP-2018386-A1 | THIAZOLYLDIHYDROINDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-28 | — | — | EP | disclosed |
| EP-2007382-A1 | THIAZOLYLDIHYDROCYCLOPENTAPYRAZOLES FOR USE AS PI3-KINASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007115930-A1 | THIAZOLYLDIHYDROINDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007115931-A1 | THIAZOLYLDIHYDROCYCLOPENTAPYRAZOLES FOR USE AS PI3-KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-18 | — | — | WO | disclosed |