Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958066 | 1.00 | HDAC1 (0.55) | HDAC1HDAC8HDAC6EGFRPDGFRB | |
| SCHEMBL3959502 | 0.99 | HDAC1 (0.55) | HDAC1HDAC8HDAC6EGFRPDGFRB | |
| SCHEMBL3962745 | 0.93 | HDAC1 (0.54) | HDAC1HDAC8HDAC6EGFRPDGFRB | |
| SCHEMBL8213390 | 0.92 | HDAC1 (0.67) | HDAC1HDAC8HDAC6EGFRPDGFRB | |
| SCHEMBL8210452 | 0.92 | HDAC1 (0.67) | HDAC1HDAC8HDAC6EGFRPDGFRB | |
| SCHEMBL13907074 | 0.91 | HDAC1 (0.67) | HDAC1HDAC8HDAC6EGFRPDGFRB | |
| SCHEMBL8204558 | 0.88 | HDAC1 (0.66) | HDAC1HDAC8HDAC6EGFRPDGFRB | |
| SCHEMBL3963840 | 0.87 | EGFR (0.57) | HDAC1HDAC8HDAC6EGFRPDGFRB | |
| SCHEMBL3954930 | 0.87 | EGFR (0.57) | HDAC1HDAC8HDAC6EGFRPDGFRB | |
| SCHEMBL3960222 | 0.86 | EGFR (0.58) | HDAC1HDAC8HDAC6EGFRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036057-A1 | ANTIPROLIFERATIVE AGENTS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |