Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP14 | P31944 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | CASP2 | P42575 | 1/20 | 0.46 |
| ▸ | CASP4 | P49662 | 1/20 | 0.46 |
| ▸ | CASP5 | P51878 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CASP9 | P55211 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.46 |
| ▸ | CASP12 | Q6UXS9 | 1/20 | 0.46 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958007 | 1.00 | EGFR (0.55) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL3964198 | 0.99 | EGFR (0.56) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL3954919 | 0.88 | EGFR (0.51) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL8204560 | 0.86 | HDAC1 (0.66) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL8213306 | 0.86 | HDAC1 (0.66) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL8204556 | 0.86 | HDAC1 (0.66) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL3954921 | 0.86 | EGFR (0.54) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL8212579 | 0.85 | HDAC1 (0.66) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL8213302 | 0.82 | HDAC1 (0.65) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL18088133 | 0.80 | HDAC1 (0.77) | EGFRPDGFRBKDRHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036057-A1 | ANTIPROLIFERATIVE AGENTS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |