Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959300 | 0.87 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTOPRM1OPRD1HDAC1 | |
| SCHEMBL3960045 | 0.85 | HDAC1 (0.53) | SMN1; SMN2MAPTOPRM1OPRD1HDAC1 | |
| SCHEMBL3963435 | 0.84 | HDAC1 (0.50) | SMN1; SMN2MAPTOPRM1OPRD1HDAC1 | |
| SCHEMBL3962774 | 0.83 | MAPT (0.52) | SMN1; SMN2MAPTOPRM1OPRD1HDAC1 | |
| SCHEMBL3957848 | 0.82 | HDAC1 (0.58) | SMN1; SMN2MAPTHDAC1ALDH1A1KDM4E | |
| SCHEMBL5002929 | 0.82 | HDAC1 (0.46) | SMN1; SMN2MAPTOPRM1OPRD1HDAC1 | |
| SCHEMBL5002927 | 0.82 | HDAC1 (0.46) | SMN1; SMN2MAPTOPRM1OPRD1HDAC1 | |
| SCHEMBL3957764 | 0.81 | HDAC1 (0.56) | SMN1; SMN2MAPTHDAC1ALDH1A1KDM4E | |
| SCHEMBL3957247 | 0.81 | HDAC3 (0.54) | SMN1; SMN2MAPTHDAC1ALDH1A1KDM4E | |
| SCHEMBL3958683 | 0.80 | HDAC1 (0.53) | SMN1; SMN2MAPTHDAC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079525-A1 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008057282-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2008-05-15 | — | — | WO | disclosed |