⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28108588 | 0.95 | — | — | |
| SCHEMBL27787581 | 0.84 | — | — | |
| SCHEMBL231115 | 0.80 | — | — | |
| SCHEMBL9383004 | 0.80 | — | — | |
| SCHEMBL270744 | 0.80 | — | — | |
| SCHEMBL2372944 | 0.79 | — | — | |
| SCHEMBL7828885 | 0.79 | — | — | |
| SCHEMBL15676 | 0.78 | — | — | |
| SCHEMBL210425 | 0.78 | — | — | |
| SCHEMBL212534 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4598 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222290-B1 | ALPHA-AMINOAMIDE DERIVATIVES FOR THE TREATMENT OF PSYCHIATRIC DISORDERS | NEWRON PHARM SPA (IT) | 2021-06-16 | — | — | EP | claimed |
| EP-2958928-B1 | ESTRA-1,3,5(10),16-TETRAENE-3-CARBOXAMIDES FOR INHIBITION OF 17.BETA.-HYDROXYSTEROID DEHYDROGENASE (AKR1 C3) | Bayer Pharma AG (DE) | 2018-03-28 | — | — | EP | claimed |
| CN-105008382-B | Estra-1, 3,5(10), 16-tetraene-3-carboxamides for the inhibition of 17 β -hydroxysteroid dehydrogenase (AKR 1C 3) | 拜耳医药股份公司 | 2018-01-30 | — | — | CN | claimed |
| US-9714266-B2 | Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1C3) | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-07-25 | — | — | US | claimed |
| CN-104961666-B | 2-mercaptoacetamide pleuromutilin derivatives, and preparation method and medical application thereof | 南通大学 | 2017-04-12 | — | — | CN | claimed |
| CN-104447450-B | Cysteine amide-type pleuromutilin derivative and preparation method and medical usage | 南通大学 | 2016-09-28 | — | — | CN | claimed |
| US-20160024142-A1 | ESTRA-1,3,5(10),16-TETRAENE-3-CARBOXAMIDES FOR INHIBITION OF 17.BETA.-HYDROXYSTEROID DEHYDROGENASE (AKR1 C3) | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-01-28 | — | — | US | claimed |
| EP-2958928-A1 | ESTRA-1,3,5(10),16-TETRAENE-3-CARBOXAMIDES FOR INHIBITION OF 17.BETA.-HYDROXYSTEROID DEHYDROGENASE (AKR1 C3) | Bayer Pharma Aktiengesellschaft (DE) | 2015-12-30 | — | — | EP | claimed |
| CN-105008382-A | Estra-1, 3,5(10), 16-tetraene-3-carboxamides for the inhibition of 17 beta-hydroxysteroid dehydrogenase (AKR 1C 3) | Bayer Pharma AG | 2015-10-28 | — | — | CN | claimed |
| CN-104961666-A | 2-mercaptoacetamide pleuromutilin derivatives, and preparation method and medical application thereof | UNIV NANTONG | 2015-10-07 | — | — | CN | claimed |
| US-6783929-B1 | COMPRISES POLYAMIDE LIGANDS FOR ENHANCED EFFICIENCY OF PROTEOMICS | CHIRON CORPORATION | 2004-08-31 | — | — | US | claimed |
| US-5190980-A | Moisturizer | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1993-03-02 | — | — | US | claimed |
| EP-0284174-B1 | THERAPEUTIC PREPARATIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-29 | — | — | EP | claimed |
| US-5004835-A | Substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), process for their production as well as X-ray contrast media containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-04-02 | — | — | US | claimed |
| EP-0176217-B1 | PYROGLUTAMIC ACID ESTERS, THEIR SYNTHESIS AND USE IN TOPICAL PRODUCTS | UNILEVER PLC (GB) | 1989-06-07 | — | — | EP | claimed |
| US-4774255-A | SKIN DISORDERS | LEVER BROTHERS COMPANY (US) | 1988-09-27 | — | — | US | claimed |
| EP-0176217-A1 | Pyroglutamic acid esters, their synthesis and use in topical products | UNILEVER PLC (GB) | 1986-04-02 | — | — | EP | claimed |
| EP-0069448-A1 | Fungicidal amide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-01-12 | — | — | EP | claimed |
| EP-0019377-B1 | 1-HYDROCARBYLOXYPHENYL-1,2-DIPHENYLALKENE DERIVATIVES, THEIR MANUFACTURE AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-08-04 | — | — | EP | claimed |
| EP-0019377-A1 | 1-Hydrocarbyloxyphenyl-1,2-diphenylalkene derivatives, their manufacture and a pharmaceutical composition containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-11-26 | — | — | EP | claimed |