Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.50 |
| ▸ | JAK3 | P52333 | 11/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | BUB1 | O43683 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958610 | 0.89 | MAPK8 (0.56) | JAK2JAK3JAK1PDGFRBFLT3 | |
| SCHEMBL3959579 | 0.87 | JAK2 (0.55) | JAK2JAK3JAK1PDGFRBFLT3 | |
| SCHEMBL3752968 | 0.86 | MAPK8 (0.61) | JAK2JAK3JAK1PDGFRBFLT3 | |
| SCHEMBL3951572 | 0.80 | MAPK8 (0.61) | JAK2JAK3JAK1PDGFRBFLT3 | |
| SCHEMBL3953204 | 0.79 | JAK2 (0.59) | JAK2JAK3JAK1PDGFRBFLT3 | |
| SCHEMBL3953494 | 0.79 | JAK2 (0.56) | JAK2JAK3IKBKBKITNEK3 | |
| SCHEMBL13081588 | 0.77 | JAK2 (0.44) | JAK2JAK3JAK1PDGFRBFLT3 | |
| SCHEMBL3954546 | 0.76 | JAK2 (0.38) | JAK2JAK3JAK1PDGFRBFLT3 | |
| SCHEMBL3759136 | 0.74 | MAPK10 (0.80) | JAK2JAK3JAK1PDGFRBFLT3 | |
| SCHEMBL3750767 | 0.73 | MAPK10 (0.73) | JAK2JAK3JAK1TYK2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200436-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |