Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | AR | P10275 | 3/20 | 0.54 |
| ▸ | FPR2 | P25090 | 6/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956206 | 0.98 | POLB (0.73) | POLBRAB9ANPC1ARFPR2 | |
| SCHEMBL240825 | 0.81 | POLB (0.73) | POLBRAB9ANPC1ARFPR2 | |
| SCHEMBL243978 | 0.80 | POLB (0.57) | POLBRAB9ANPC1ARFPR2 | |
| SCHEMBL13879418 | 0.79 | POLB (0.66) | POLBRAB9ANPC1ARFPR2 | |
| SCHEMBL31271900 | 0.79 | POLB (0.47) | POLBRAB9ANPC1ARFPR2 | |
| SCHEMBL11469297 | 0.79 | AR (0.64) | POLBRAB9ANPC1ARFPR2 | |
| SCHEMBL13879542 | 0.79 | POLB (0.65) | POLBRAB9ANPC1ARLMNA | |
| SCHEMBL242108 | 0.78 | POLB (0.72) | POLBRAB9ANPC1ARAKR1B1 | |
| SCHEMBL242688 | 0.78 | POLB (0.68) | POLBRAB9ANPC1ARALDH1A1 | |
| SCHEMBL13879525 | 0.76 | POLB (0.65) | POLBRAB9ANPC1ARAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034062-A1 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034062-A1 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |