Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2090145 | 0.72 | MAPT (0.49) | KDM4EALDH1A1CYP2C19MAPTKMT2A | |
| SCHEMBL373131 | 0.68 | GAA (0.72) | ALDH1A1MAPTGAACHRM2CHRM1 | |
| SCHEMBL3966081 | 0.68 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10CYP2C19LMNA | |
| SCHEMBL11114287 | 0.68 | MAPT (0.68) | KDM4EALDH1A1CYP2C19LMNAMAPT | |
| SCHEMBL27662340 | 0.68 | MAPT (0.68) | KDM4EALDH1A1CYP2C19MAPTKMT2A | |
| SCHEMBL31611860 | 0.67 | CYP2C19 (0.73) | KDM4EALDH1A1HSD17B10CYP2C19LMNA | |
| SCHEMBL6376333 | 0.66 | HCRTR1 (0.55) | KDM4EALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL14413875 | 0.66 | KDM4E (0.71) | KDM4EALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL1459283 | 0.66 | MEN1 (0.52) | KDM4EALDH1A1CYP2C19LMNAMAPT | |
| SCHEMBL6293462 | 0.66 | MAPT (0.70) | KDM4EALDH1A1CYP2C19MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069346-A1 | ACETAMIDE AND CARBOXAMIDE DERIVATIVES OF AZAADAMANTANE AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008118743-A1 | ACETAMIDE AND CARBOXAMIDE DERIVATIVES OF AZAADAMANTANE AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2008-10-02 | — | — | WO | disclosed |