Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.60 |
| ▸ | JAK3 | P52333 | 16/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | JAK1 | P23458 | 14/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | CIT | O14578 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | OPA1 | O60313 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | STK16 | O75716 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | MARK3 | P27448 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | STAT5A | P42229 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3953685 | 0.92 | JAK2 (0.59) | JAK2JAK3HDAC1JAK1BMPR1B | |
| SCHEMBL3955441 | 0.89 | JAK2 (0.62) | JAK2JAK3HDAC1JAK1BMPR1B | |
| SCHEMBL3958904 | 0.86 | JAK2 (0.63) | JAK2JAK3HDAC1JAK1BMPR1B | |
| SCHEMBL3956469 | 0.85 | JAK2 (0.59) | JAK2JAK3HDAC1JAK1BMPR1B | |
| SCHEMBL4383495 | 0.84 | JAK2 (0.69) | JAK2JAK3HDAC1JAK1TYK2 | |
| SCHEMBL3618886 | 0.84 | JAK2 (0.79) | JAK2JAK3HDAC1JAK1BMPR1B | |
| Hydrochloric Acid SCHEMBL2863016 | 0.83 | JAK2 (0.78) | JAK2JAK3HDAC1JAK1BMPR1B | |
| SCHEMBL3956574 | 0.82 | JAK2 (0.75) | JAK2JAK3HDAC1JAK1TYK2 | |
| SCHEMBL3954596 | 0.82 | JAK2 (0.60) | JAK2JAK3HDAC1JAK1BMPR1B | |
| SCHEMBL3619660 | 0.81 | JAK2 (0.75) | JAK2JAK3HDAC1JAK1BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029998-A1 | RETROMETABOLIC COMPOUNDS | CYTOPIA RESEARCH PTY LTD (AU) | 2009-03-12 | — | — | WO | claimed |
| WO-2009029998-A1 | RETROMETABOLIC COMPOUNDS | CYTOPIA RESEARCH PTY LTD (AU) | 2009-03-12 | — | — | WO | disclosed |