Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 13/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | SRC | P12931 | 4/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4082979 | 0.91 | FGFR1 (0.43) | FGFR1EGFRSRCFGFR2FGFR4 | |
| Hydrochloric Acid SCHEMBL3967077 | 0.86 | BRD4 (0.41) | FGFR1EGFRSRCFGFR2FGFR4 | |
| Trifluoroacetic Acid SCHEMBL3964521 | 0.85 | FGFR1 (0.42) | FGFR1EGFRSRCFGFR2FGFR4 | |
| Hydrochloric Acid SCHEMBL3964587 | 0.85 | JAK2 (0.41) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL3970084 | 0.83 | FGFR1 (0.45) | FGFR1EGFRSRCFGFR2FGFR4 | |
| Hydrochloric Acid SCHEMBL3962134 | 0.82 | FGFR1 (0.40) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL3963837 | 0.82 | FGFR1 (0.44) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL3965368 | 0.82 | FGFR1 (0.42) | FGFR1EGFRSRCFGFR2FGFR4 | |
| Hydrochloric Acid SCHEMBL3958563 | 0.81 | FGFR1 (0.42) | FGFR1EGFRSRCFGFR2FGFR4 | |
| Hydrochloric Acid SCHEMBL3963641 | 0.80 | FGFR1 (0.45) | FGFR1EGFRSRCFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |