⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopentane SCHEMBL5213547 | 0.92 | TSHR (0.38) | — | |
| Cyclohexane SCHEMBL5213648 | 0.92 | TSHR (0.38) | — | |
| Cyclopropane SCHEMBL5215543 | 0.92 | TSHR (0.38) | — | |
| SCHEMBL10597413 | 0.77 | — | — | |
| SCHEMBL28442462 | 0.77 | — | — | |
| SCHEMBL3182447 | 0.73 | TSHR (0.47) | — | |
| SCHEMBL3057906 | 0.73 | — | — | |
| SCHEMBL6278211 | 0.73 | TSHR (0.47) | — | |
| SCHEMBL11841196 | 0.73 | — | — | |
| SCHEMBL9180399 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10988539-B2 | Combination therapy with anti-HLA-DR antibodies and kinase inhibitors in hematopoietic cancers | IMMUNOMEDICS, INC. (US) | 2021-04-27 | — | — | US | disclosed |
| US-20170239368-A1 | Immunoconjugates with an Intracellularly-Cleavable Linkage | IMMUNOMEDICS, INC. | 2017-08-24 | — | — | US | disclosed |
| EP-2396036-B1 | IMMUNOCONJUGATES WITH AN INTRACELLULARLY-CLEAVABLE LINKAGE | IMMUNOMEDICS INC (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2078012-A2 | THROMBIN RECEPTOR ANTAGONISTS BASED ON THE MODIFIED TRICYCLIC UNIT OF HIMBACINE | SCHERING CORPORATION (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008060372-A2 | THROMBIN RECEPTOR ANTAGONISTS BASED ON THE MODIFIED TRICYCLIC UNIT OF HIMBACINE | SCHERING CORPORATION (US) | 2008-05-22 | — | — | WO | disclosed |
| US-20080085923-A1 | Thrombin Receptor Antagonists Based On The Modified Tricyclic Unit Of Himbacine | SCHERING CORPORATION | 2008-04-10 | — | — | US | disclosed |
| EP-1181283-A1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075120-A1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2000-12-14 | — | — | WO | disclosed |
| EP-0452170-A1 | 1,2,5,6-Tetrahydropyridin-3-carboxaldehyde oxime derivatives, process for their preparation and their use as drugs | ROUSSEL-UCLAF (FR) | 1991-10-16 | — | — | EP | disclosed |
| US-4051250-A | OXAZOLE, THIAZOLE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-27 | — | — | US | disclosed |
| US-3933840-A | ANTIPHLOGISTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1976-01-20 | — | — | US | disclosed |