Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.69 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.69 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.69 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
| ▸ | LYN | P07948 | 1/20 | 0.69 |
| ▸ | RET | P07949 | 1/20 | 0.69 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.69 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.69 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.69 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.69 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.69 |
| ▸ | ADK | P55263 | 1/20 | 0.69 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.69 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 3/20 | 0.67 |
| ▸ | FLT1 | P17948 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL203146 | 1.00 | EGFR (0.79) | EGFRERBB2EPHA2EPHB4GAK | |
| SCHEMBL31050075 | 1.00 | EGFR (0.79) | EGFRERBB2EPHA2EPHB4GAK | |
| Hydrochloric Acid SCHEMBL4081444 | 0.99 | EGFR (0.78) | EGFRERBB2EPHA2EPHB4GAK | |
| Hydrochloric Acid SCHEMBL201989 | 0.99 | EGFR (0.78) | EGFRERBB2EPHA2EPHB4GAK | |
| Hydrochloric Acid SCHEMBL2455816 | 0.99 | EGFR (0.78) | EGFRERBB2EPHA2EPHB4GAK | |
| Alcohol SCHEMBL5426837 | 0.95 | EGFR (0.72) | EGFRERBB2EPHA2EPHB4GAK | |
| SCHEMBL3134269 | 0.95 | EGFR (0.74) | EGFRERBB2EPHA2EPHB4GAK | |
| Hydrochloric Acid SCHEMBL3131145 | 0.94 | EGFR (0.73) | EGFRERBB2EPHA2EPHB4GAK | |
| Hydrochloric Acid SCHEMBL3965089 | 0.94 | EGFR (0.73) | EGFRERBB2EPHA2EPHB4GAK | |
| Hydrochloric Acid SCHEMBL3123628 | 0.94 | EGFR (0.73) | EGFRERBB2EPHA2EPHB4GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237610-A1 | Quinazoline Derivatives as Antiproliferative Agents | ASTRAZENECA AB (SE) | 2011-09-29 | — | — | US | disclosed |
| US-20110237610-A1 | Quinazoline Derivatives as Antiproliferative Agents | ASTRAZENECA AB (SE) | 2011-09-29 | — | — | US | disclosed |
| US-7838530-B2 | Quinazoline derivatives as antiproliferative agents | ASTRAZENECA AB (SE) | 2010-11-23 | — | — | US | disclosed |
| US-7838530-B2 | Quinazoline derivatives as antiproliferative agents | ASTRAZENECA AB (SE) | 2010-11-23 | — | — | US | disclosed |
| US-20090312343-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | HENNEQUIN LAURENT FRANCOIS AND | 2009-12-17 | — | — | US | disclosed |
| US-7569577-B2 | Quinazoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2009-08-04 | — | — | US | disclosed |
| EP-1667996-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-07-22 | — | — | EP | disclosed |
| EP-1667991-B1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-14 | — | — | EP | disclosed |
| US-20070043009-A1 | Quinazoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | US | disclosed |
| US-20070032513-A1 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
| EP-1667991-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | Astrazeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| EP-1667996-A1 | QUINAZOLINE DERIVATIVES | Astrazeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| EP-1668006-A1 | QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | AstraZeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030765-A1 | QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | disclosed |
| WO-2005026150-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |
| WO-2005026157-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312343-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ERBB2, ABL1, EGFR | EGFR 3/4885ERBB2 1/4885EPHA2 220/4885 |
| US-20110237610-A1 | Quinazoline Derivatives as Antiproliferative Agents | ERBB2, EGFR, MKI67 | EGFR 2/4885ERBB2 1/4885EPHA2 584/4885 |
| US-20070032513-A1 | Quinazoline derivatives | ERBB2, EGFR, ABL1 | EGFR 2/4885ERBB2 1/4885EPHA2 241/4885 |
| US-20070043009-A1 | Quinazoline derivatives as tyrosine kinase inhibitors | ERBB2, ABL1, EGFR | EGFR 3/4885ERBB2 1/4885EPHA2 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.