Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.68 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.68 |
| ▸ | RAF1 | P04049 | 4/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
| ▸ | SRC | P12931 | 1/20 | 0.68 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10091921 | 1.00 | NTRK1 (0.68) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL396704 | 0.90 | NTRK1 (0.76) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL396703 | 0.90 | NTRK1 (0.76) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL396894 | 0.89 | NTRK2 (0.69) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL10091918 | 0.89 | NTRK2 (0.69) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL396224 | 0.87 | NTRK1 (0.65) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL4124627 | 0.86 | NTRK1 (0.71) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL4002779 | 0.86 | NTRK1 (0.71) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL396340 | 0.86 | NTRK2 (0.69) | NTRK1NTRK2RAF1AURKASRC | |
| SCHEMBL10091887 | 0.86 | NTRK2 (0.69) | NTRK1NTRK2RAF1AURKASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | claimed |
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | disclosed |