Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332158 | 1.00 | SPHK1 (0.35) | SPHK1BRD4MMP13MEN1KMT2A | |
| SCHEMBL2332146 | 1.00 | SPHK1 (0.35) | SPHK1BRD4MMP13MEN1KMT2A | |
| SCHEMBL2332163 | 1.00 | SPHK1 (0.35) | SPHK1BRD4MMP13MEN1KMT2A | |
| SCHEMBL2332152 | 1.00 | SPHK1 (0.35) | SPHK1BRD4MMP13MEN1KMT2A | |
| SCHEMBL2322332 | 0.90 | ABCG2 (0.34) | SPHK1BRD4MMP13MEN1KMT2A | |
| SCHEMBL2322323 | 0.90 | ABCG2 (0.34) | SPHK1BRD4MMP13MEN1KMT2A | |
| SCHEMBL2322318 | 0.90 | ABCG2 (0.34) | SPHK1BRD4MMP13MEN1KMT2A | |
| SCHEMBL2322328 | 0.90 | ABCG2 (0.34) | SPHK1BRD4MMP13MEN1KMT2A | |
| SCHEMBL8240970 | 0.90 | SPHK1 (0.33) | SPHK1BRD4MMP13MEN1KMT2A | |
| SCHEMBL4755858 | 0.89 | STAT3 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081927-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008036216-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |