Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | TEC | P42680 | 1/20 | 0.45 |
| ▸ | TXK | P42681 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | BMX | P51813 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965301 | 0.93 | BTK (0.55) | BTKCLK2TYK2 | |
| SCHEMBL3961624 | 0.85 | BTK (0.61) | BTKCLK2 | |
| SCHEMBL1322006 | 0.84 | BTK (0.82) | BTKCLK2 | |
| SCHEMBL3964890 | 0.80 | BTK (0.61) | BTKCLK2JAK2INSRIGF1R | |
| SCHEMBL1322606 | 0.79 | BTK (0.77) | BTKCLK2JAK2INSRIGF1R | |
| SCHEMBL1321952 | 0.78 | BTK (0.74) | BTKCLK2 | |
| SCHEMBL3655714 | 0.76 | BTK (0.66) | BTKCLK2JAK2INSRIGF1R | |
| SCHEMBL5242071 | 0.76 | BTK (0.66) | BTKJAK2INSRIGF1RCYP3A4 | |
| SCHEMBL102343 | 0.75 | BTK (1.00) | BTKCLK2 | |
| SCHEMBL104439 | 0.75 | BTK (0.77) | BTKCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081923-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008033854-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |