⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10936877 | 0.61 | — | — | |
| SCHEMBL14746363 | 0.60 | — | — | |
| SCHEMBL17232939 | 0.60 | — | — | |
| SCHEMBL9959291 | 0.56 | — | — | |
| SCHEMBL6163592 | 0.52 | — | — | |
| SCHEMBL3628672 | 0.47 | — | — | |
| SCHEMBL28052554 | 0.46 | — | — | |
| SCHEMBL5888231 | 0.45 | — | — | |
| SCHEMBL5100457 | 0.44 | — | — | |
| SCHEMBL12079523 | 0.38 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101426771-B | Process for manufacturing diazepine derivatives | HOFFMANN LA ROCHE | 2011-11-16 | — | — | CN | disclosed |
| CN-101426771-A | Process for manufacturing diazepine derivatives | HOFFMANN LA ROCHE (CH) | 2009-05-06 | — | — | CN | disclosed |
| US-7517874-B2 | Substituted imidazo[1,5-a][1,4]diazepines and imidazo[1,5-a]pyrazines as cannabinoid receptor agonists for the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| EP-1202977-B1 | PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-12-17 | — | — | EP | disclosed |
| EP-1202977-B1 | PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-12-17 | — | — | EP | disclosed |
| EP-1202977-A2 | PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-08 | — | — | EP | disclosed |
| EP-1202977-A2 | PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-08 | — | — | EP | disclosed |
| WO-2000069835-A3 | PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2002-03-07 | — | — | WO | disclosed |
| US-6281353-B1 | EXPANSION WITH AN AMINECARBOXY COMPOUND THE CORRESPONDING3,1-BENZOXAZIN-2,4-DIONE COMPOUND | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000069835-A2 | PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-11-23 | — | — | WO | disclosed |
| US-4346032-A | ANTIDOTES TO OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346034-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346035-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346036-A | ALKYLATION; AMIDATION; TRANQUILIZER ANTAGONIST | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346031-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4316839-A | Imidazodiazepine derivatives | HOFFMAN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | disclosed |
| US-4307237-A | ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1981-12-22 | — | — | US | disclosed |
| US-4280957-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
| US-4280957-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
| EP-0027214-A1 | Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-22 | — | — | EP | disclosed |