Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL396457 | 0.91 | KDR (0.38) | NTRK1NTRK3KDRKITFGFR1 | |
| SCHEMBL395051 | 0.85 | NTRK1 (0.45) | NTRK1NTRK3NTRK2POLBCTDSP1 | |
| SCHEMBL399189 | 0.85 | NTRK1 (0.46) | NTRK1NTRK3NTRK2POLBCTDSP1 | |
| SCHEMBL398657 | 0.80 | NTRK1 (0.37) | NTRK1NTRK3NTRK2KDRBRAF | |
| SCHEMBL395940 | 0.77 | NTRK1 (0.61) | NTRK1NTRK3NTRK2POLBCTDSP1 | |
| SCHEMBL395941 | 0.77 | NTRK1 (0.61) | NTRK1NTRK3NTRK2POLBCTDSP1 | |
| SCHEMBL393968 | 0.77 | NTRK1 (0.44) | NTRK1NTRK3NTRK2POLBCTDSP1 | |
| SCHEMBL396227 | 0.76 | NTRK1 (0.45) | NTRK1NTRK3NTRK2POLBCTDSP1 | |
| SCHEMBL4125355 | 0.75 | NTRK1 (0.61) | NTRK1NTRK3NTRK2POLBCTDSP1 | |
| SCHEMBL4131689 | 0.75 | NTRK1 (0.61) | NTRK1NTRK3NTRK2POLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | claimed |
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | disclosed |