⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12362395 | 0.67 | — | — | |
| SCHEMBL2751289 | 0.67 | — | — | |
| SCHEMBL9940294 | 0.67 | HIF1A (0.39) | — | |
| SCHEMBL9751684 | 0.67 | — | — | |
| SCHEMBL2283017 | 0.63 | — | — | |
| SCHEMBL2752712 | 0.63 | — | — | |
| SCHEMBL17668147 | 0.60 | — | — | |
| SCHEMBL73703 | 0.60 | — | — | |
| SCHEMBL4338859 | 0.60 | — | — | |
| SCHEMBL11276924 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879591-B1 | USE OF AZAPAULLONES FOR PREVENTING AND TREATING PANCREATIC AUTOIMMUNE DISORDERS | DEVELOGEN AG (DE) | 2012-01-25 | — | — | EP | disclosed |
| US-7968535-B2 | Antidiabetic agents; neurodegenerative disorders; mixture with immunosuppresants | DEVELOGEN ATKIENGESELLSCHAFT (DE) | 2011-06-28 | — | — | US | disclosed |
| WO-2009010298-A2 | PAULLONE DERIVATIVES AND ITS USE | TECHNISCHE UNIVERSITÄT CAROLO-WILHELMINA ZU BRAUNSCHWEIG (DE) | 2009-01-22 | — | — | WO | disclosed |
| US-20080287423-A1 | Use of Azapaullones For Preventing and Treating Pancreatic Autoimmune Disorders | EVOTEC INTERNATIONAL GMBH (DE) | 2008-11-20 | — | — | US | disclosed |
| EP-1879591-A1 | USE OF AZAPAULLONES FOR PREVENTING AND TREATING PANCREATIC AUTOIMMUNE DISORDERS | DeveloGen Aktiengesellschaft (DE) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117221-A1 | USE OF AZAPAULLONES FOR PREVENTING AND TREATING PANCREATIC AUTOIMMUNE DISORDERS | DEVELOGEN AKTIENGESELLSCHAFT (DE) | 2006-11-09 | — | — | WO | disclosed |