Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.62 |
| ▸ | CCND1 | P24385 | 2/20 | 0.62 |
| ▸ | CCND2 | P30279 | 2/20 | 0.62 |
| ▸ | CCND3 | P30281 | 2/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 13/20 | 0.57 |
| ▸ | NOD2 | Q9HC29 | 13/20 | 0.57 |
| ▸ | ACVR1 | Q04771 | 10/20 | 0.54 |
| ▸ | WEE1 | P30291 | 5/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971273 | 0.86 | CDK4 (0.63) | CDK4CCND1CCND2CCND3RIPK2 | |
| SCHEMBL3971155 | 0.80 | EGFR (0.65) | CDK4CCND1CCND2CCND3WEE1 | |
| SCHEMBL3972439 | 0.79 | CDK4 (0.68) | CDK4CCND1CCND2CCND3RIPK2 | |
| SCHEMBL3972205 | 0.78 | CDK4 (0.60) | CDK4CCND1CCND2CCND3RIPK2 | |
| SCHEMBL5264440 | 0.77 | CDK4 (1.00) | CDK4CCND1CCND2CCND3RIPK2 | |
| SCHEMBL16446474 | 0.75 | RIPK2 (0.62) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL20564685 | 0.73 | RIPK2 (1.00) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL6620615 | 0.72 | LCK (0.67) | CDK4CCND1CCND2CCND3RIPK2 | |
| SCHEMBL3977348 | 0.72 | PDE1B (0.45) | — | |
| SCHEMBL4353287 | 0.71 | CDK4 (1.00) | CDK4CCND1CCND2CCND3RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501425-B1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyprimidines as inhibitors of cellular proliferation | WARNER LAMBERT COMPANY (US) | 2009-03-10 | — | — | US | disclosed |
| EP-1080092-B1 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1801112-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20040044012-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | DOBRUSIN ELLEN MYRA (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044012-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | CCNI, CCNH, CCNA1 | CDK4 4/4885CCND1 13/4885CCND2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.