Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 0.69 |
| ▸ | JAK2 | O60674 | 5/20 | 0.69 |
| ▸ | FLT3 | P36888 | 3/20 | 0.69 |
| ▸ | JAK1 | P23458 | 2/20 | 0.69 |
| ▸ | BRD2 | P25440 | 2/20 | 0.69 |
| ▸ | JAK3 | P52333 | 2/20 | 0.69 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.69 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.69 |
| ▸ | BUB1B | O60566 | 1/20 | 0.69 |
| ▸ | RET | P07949 | 1/20 | 0.69 |
| ▸ | WEE1 | P30291 | 1/20 | 0.69 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13881489 | 0.83 | BRD4 (0.54) | BRD4JAK2FLT3JAK1BRD2 | |
| SCHEMBL13881536 | 0.83 | JAK2 (0.71) | BRD4JAK2FLT3JAK1BRD2 | |
| SCHEMBL31163083 | 0.82 | BRD4 (1.00) | BRD4JAK2FLT3JAK1BRD2 | |
| SCHEMBL29432552 | 0.82 | BRD4 (1.00) | BRD4JAK2FLT3JAK1BRD2 | |
| SCHEMBL265061 | 0.82 | BRD4 (1.00) | BRD4JAK2FLT3JAK1BRD2 | |
| SCHEMBL18225182 | 0.79 | BRD4 (0.78) | BRD4JAK2FLT3JAK1BRD2 | |
| SCHEMBL17526335 | 0.77 | BRD4 (1.00) | BRD4JAK2FLT3JAK1BRD2 | |
| SCHEMBL30306487 | 0.77 | BRD4 (1.00) | BRD4JAK2FLT3JAK1BRD2 | |
| SCHEMBL519462 | 0.77 | JAK2 (1.00) | BRD4JAK2FLT3JAK1BRD2 | |
| SCHEMBL14536137 | 0.76 | BRD4 (0.89) | BRD4JAK2FLT3JAK1BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |