Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 15/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969955 | 0.84 | FGFR4 (0.49) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL3975638 | 0.83 | FGFR4 (0.75) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL3968638 | 0.80 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL4404764 | 0.79 | FGFR1 (0.57) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16059513 | 0.79 | FGFR4 (0.63) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16062067 | 0.78 | FGFR4 (0.63) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16071567 | 0.78 | FGFR4 (0.66) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL3967544 | 0.78 | FGFR4 (0.56) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16134055 | 0.77 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL1521523 | 0.76 | FGFR4 (0.41) | FGFR4FGFR1FGFR2FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501425-B1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyprimidines as inhibitors of cellular proliferation | WARNER LAMBERT COMPANY (US) | 2009-03-10 | — | — | US | disclosed |
| EP-1080092-B1 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1801112-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20040044012-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | DOBRUSIN ELLEN MYRA (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044012-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | CCNI, CCNH, CCNA1 | FGFR4 95/4885FGFR1 55/4885FGFR2 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.