Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 2/20 | 0.54 |
| ▸ | TLR2 | O60603 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27996038 | 0.85 | TLR4 (0.48) | TLR4TLR2MAOAMAOBPARP10 | |
| SCHEMBL24196243 | 0.82 | KDM4E (0.51) | TLR4TLR2MAOAMAOBPARP10 | |
| SCHEMBL31220919 | 0.82 | TLR4 (0.50) | TLR4TLR2MAOAMAOBPARP10 | |
| SCHEMBL4569158 | 0.82 | TLR4 (0.50) | TLR4TLR2MAOAMAOBPARP10 | |
| SCHEMBL2208831 | 0.82 | TLR4 (0.50) | TLR4TLR2MAOAMAOBPARP10 | |
| SCHEMBL8069925 | 0.81 | PARP10 (0.56) | MAOAMAOBPARP10PARP15 | |
| SCHEMBL2208063 | 0.81 | TLR4 (0.66) | TLR4TLR2MAOAMAOBPARP10 | |
| SCHEMBL2204448 | 0.81 | TLR4 (0.66) | TLR4TLR2MAOAMAOBPARP10 | |
| SCHEMBL2207924 | 0.81 | TLR4 (0.66) | TLR4TLR2MAOAMAOBPARP10 | |
| SCHEMBL31220908 | 0.81 | TLR4 (0.66) | TLR4TLR2MAOAMAOBPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |