Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 16/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 14/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968497 | 0.92 | FGFR4 (0.52) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL3967144 | 0.91 | CDK1 (0.43) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL3970268 | 0.88 | FGFR3 (0.47) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL3976966 | 0.86 | CDK1 (0.53) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL3975654 | 0.86 | FGFR3 (0.46) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL3971204 | 0.81 | FGFR1 (0.53) | FGFR2FGFR3FGFR4FGFR1 | |
| SCHEMBL3971306 | 0.79 | FGFR4 (0.53) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL3968636 | 0.78 | EGFR (0.53) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL3971767 | 0.74 | FGFR4 (0.62) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL3976088 | 0.74 | FGFR4 (0.53) | CDK1CDK4CCNB1CCND1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1801112-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-06-27 | — | — | EP | claimed |
| US-7501425-B1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyprimidines as inhibitors of cellular proliferation | WARNER LAMBERT COMPANY (US) | 2009-03-10 | — | — | US | disclosed |
| EP-1801112-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20040044012-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | DOBRUSIN ELLEN MYRA (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044012-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | CCNI, CCNH, CCNA1 | CDK1 11/4885CDK4 4/4885CCNB1 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.