Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 15/20 | 0.83 |
| ▸ | CCND1 | P24385 | 12/20 | 0.83 |
| ▸ | CCND2 | P30279 | 11/20 | 0.83 |
| ▸ | CCND3 | P30281 | 11/20 | 0.83 |
| ▸ | AURKA | O14965 | 2/20 | 0.73 |
| ▸ | CSF1R | P07333 | 2/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.60 |
| ▸ | CDK2 | P24941 | 6/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.60 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.60 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.60 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 4/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264096 | 0.91 | CDK4 (1.00) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL3977658 | 0.89 | CDK4 (0.67) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL3972941 | 0.88 | CDK4 (0.66) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL12639089 | 0.87 | CDK4 (0.75) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL12305095 | 0.87 | CDK4 (0.75) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL12639643 | 0.86 | CDK4 (0.73) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL3970463 | 0.82 | CDK4 (0.81) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL3972389 | 0.82 | CDK4 (0.68) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL3971192 | 0.82 | CDK4 (0.58) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL5262740 | 0.81 | CDK4 (0.83) | CDK4CCND1CCND2CCND3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501425-B1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyprimidines as inhibitors of cellular proliferation | WARNER LAMBERT COMPANY (US) | 2009-03-10 | — | — | US | claimed |
| EP-1080092-B1 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2008-07-23 | — | — | EP | claimed |
| EP-1801112-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-06-27 | — | — | EP | claimed |
| US-7501425-B1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyprimidines as inhibitors of cellular proliferation | WARNER LAMBERT COMPANY (US) | 2009-03-10 | — | — | US | disclosed |
| EP-1080092-B1 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1801112-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20040044012-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | DOBRUSIN ELLEN MYRA (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044012-A1 | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation | CCNI, CCNH, CCNA1 | CDK4 4/4885CCND1 13/4885CCND2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.