SCHEMBL3968653

SCHEMBL3968653

CC(=O)Nc1ccc(OC2(C(C)=O)C=CC=CC2C(=O)O)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.44
MEN1 O00255 3/20 0.44
LMNA P02545 1/20 0.41
CYP1A2 P05177 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
MAPT P10636 3/20 0.40
ALDH1A1 P00352 2/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
SMN1; SMN2 Q16637 4/20 0.39
POLB P06746 2/20 0.39
HTT P42858 2/20 0.38
HSD17B10 Q99714 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NAPRT Q6XQN6 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8413587 0.66
SCHEMBL31403412 0.65 MEN1 (0.58) KMT2AMEN1LMNACYP1A2TDP1
SCHEMBL29187605 0.65
SCHEMBL27518510 0.65 KMT2A (0.53) KMT2AMEN1LMNACYP1A2TDP1
SCHEMBL6516221 0.65 KMT2A (0.73) KMT2AMEN1LMNACYP1A2TDP1
SCHEMBL11447100 0.64 KMT2A (0.56) KMT2AMEN1LMNACYP1A2TDP1
SCHEMBL11447038 0.64 NPC1 (0.61) KMT2AMEN1LMNACYP1A2TDP1
SCHEMBL27816274 0.64 KMT2A (0.78) KMT2AMEN1LMNACYP1A2TDP1
SCHEMBL861674 0.64 SMN1; SMN2 (0.84) KMT2AMEN1TDP1MAPTALDH1A1
SCHEMBL6751835 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2065047-A1 Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein Board of Regents, The University of Texas System (US) 2009-06-03 EP disclosed
EP-1214940-B1 Methods of enhancing the therapeutic activity of NSAIDs and compositions of zwitterionic phospholipids useful therein UNIV TEXAS (US) 2009-03-11 EP disclosed
EP-1214940-A1 Methods of enhancing the therapeutic activity of NSAIDs and compositions of zwitterionic phospholipids useful therein THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2002-06-19 EP disclosed
EP-0805684-B1 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN UNIV TEXAS (US) 2002-06-12 EP disclosed
US-5955451-A NONSTEROID ANTIINFLAMMATORY AGENTS COMPLEXED WITH ZWITTERIONS OR PHOSPHOLIPIDS FOR NONIRRITATION OF GASTROINTESTINAL SYSTEMS AND ANTIPYRETICS THE UNIVERSITY OF TEXAS SYSTEM BOARD OF REGENTS 1999-09-21 US disclosed
WO-1998013073-A9 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN 1998-08-06 WO disclosed
EP-0805684-A4 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN UNIV TEXAS (US) 1998-08-05 EP disclosed
US-5763422-A Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1998-06-09 US disclosed
WO-1998013073-A1 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1998-04-02 WO disclosed
EP-0805684-A2 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1997-11-12 EP disclosed
WO-1996022780-A1 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 1996-08-01 WO disclosed
US-4528193-A Inflammation-preventing pharmaceutical composition of oral administration A. NATTERMAN & CIE. GMBH (DE) 1985-07-09 US disclosed
US-4421747-A PHOSPHOLIPID AND DERIVATIVE OF PHENYLACETIC OR PHENYLPROPIONIC ACID A. NATTERMANN & CIE. GMBH (DE) 1983-12-20 US disclosed
US-4378354-A CONSISTING OF A PHOSPHOLIPID AND SALICYLIC ACID OR DERIVATIVE A. NATTERMANN & CIE. GMBH (DE) 1983-03-29 US disclosed
US-4369182-A Inflammation-preventing pharmaceutical composition of oral administration A. NATTERMANN & CIE GMBH (DE) 1983-01-18 US disclosed
US-4332795-A INDOLE COMPOUND AND PHOSPHOLIPID A. NATTERMANN & CIE. GMBH (DE) 1982-06-01 US disclosed