Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3869129 | 0.89 | TOP1 (0.45) | HSD17B10KDM4EALDH1A1HPGDSTAT3 | |
| SCHEMBL584797 | 0.87 | STAT3 (0.53) | HSD17B10KDM4EALDH1A1HPGDSTAT3 | |
| SCHEMBL8503513 | 0.85 | KDM4E (0.53) | HSD17B10KDM4EALDH1A1HPGDPMP22 | |
| SCHEMBL9233680 | 0.85 | KDM4E (0.41) | HSD17B10KDM4EALDH1A1HPGDSTAT3 | |
| SCHEMBL3820416 | 0.83 | TOP1 (0.44) | HSD17B10KDM4EALDH1A1HPGDSTAT3 | |
| SCHEMBL9233676 | 0.82 | KDM4E (0.51) | HSD17B10KDM4EALDH1A1HPGDPMP22 | |
| SCHEMBL12917038 | 0.82 | STAT3 (0.49) | HSD17B10KDM4EALDH1A1HPGDSTAT3 | |
| SCHEMBL964499 | 0.81 | STAT3 (0.52) | HSD17B10KDM4EALDH1A1HPGDSTAT3 | |
| SCHEMBL12917147 | 0.79 | STAT3 (0.36) | HSD17B10KDM4EALDH1A1HPGDSTAT3 | |
| SCHEMBL12917115 | 0.79 | KDM4E (0.45) | HSD17B10KDM4EALDH1A1HPGDPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013182-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | Activx Biosciences, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007106537-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2007-09-20 | — | — | WO | disclosed |