Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK2 | Q16620 | 9/20 | 0.86 |
| ▸ | NTRK1 | P04629 | 14/20 | 0.72 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGR | P09769 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL396974 | 1.00 | NTRK2 (0.86) | NTRK2NTRK1SRCAURKARAF1 | |
| SCHEMBL398639 | 0.95 | NTRK2 (0.86) | NTRK2NTRK1SRCAURKARAF1 | |
| SCHEMBL398638 | 0.95 | NTRK2 (0.86) | NTRK2NTRK1SRCAURKARAF1 | |
| SCHEMBL398254 | 0.92 | NTRK2 (1.00) | NTRK2NTRK1SRCAURKARAF1 | |
| SCHEMBL398255 | 0.92 | NTRK2 (1.00) | NTRK2NTRK1SRCAURKARAF1 | |
| SCHEMBL10091988 | 0.87 | NTRK2 (0.75) | NTRK2NTRK1SRCAURKARAF1 | |
| SCHEMBL397883 | 0.85 | NTRK1 (0.80) | NTRK2NTRK1SRCAURKARAF1 | |
| SCHEMBL397882 | 0.85 | NTRK1 (0.80) | NTRK2NTRK1SRCAURKARAF1 | |
| SCHEMBL396447 | 0.85 | NTRK2 (0.85) | NTRK2NTRK1SRCAURKARAF1 | |
| SCHEMBL396446 | 0.85 | NTRK2 (0.85) | NTRK2NTRK1SRCAURKARAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | claimed |