Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968673 | 0.92 | DPP4 (0.53) | DPP4CHRM1CHRM2CHRM3KCNH2 | |
| SCHEMBL3971411 | 0.90 | DPP4 (0.56) | DPP4CHRM1 | |
| SCHEMBL3970697 | 0.90 | DPP4 (0.48) | DPP4CHRM1CHRM2CHRM3KCNH2 | |
| SCHEMBL3971376 | 0.89 | DPP4 (0.54) | DPP4CHRM1CHRM2CHRM3KCNH2 | |
| SCHEMBL3966202 | 0.88 | DPP4 (0.46) | DPP4CHRM1CHRM2CHRM3KCNH2 | |
| SCHEMBL3966412 | 0.88 | DPP4 (0.47) | DPP4CHRM1CHRM2CHRM3KCNH2 | |
| SCHEMBL3968438 | 0.88 | DPP4 (0.48) | DPP4CHRM1CHRM2CHRM3KCNH2 | |
| SCHEMBL3964246 | 0.87 | DPP4 (0.49) | DPP4CHRM1CHRM2CHRM3KCNH2 | |
| SCHEMBL3971099 | 0.87 | DPP4 (0.52) | DPP4CHRM1CHRM2CHRM3KCNH2 | |
| SCHEMBL3967659 | 0.86 | DPP4 (0.60) | DPP4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569574-B2 | Purine derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-08-04 | — | — | US | disclosed |
| EP-1532150-B1 | NOVEL PURINE DERIVATIVES, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1532150-A1 | NOVEL PURINE DERIVATIVES, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004018469-A1 | NOVEL PURINE DERIVATIVES, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-04 | — | — | WO | disclosed |