Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 19/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3965763 | 0.93 | FGFR1 (0.54) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| Trifluoroacetic Acid SCHEMBL3965439 | 0.93 | FGFR1 (0.48) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| Trifluoroacetic Acid SCHEMBL4071955 | 0.93 | FGFR1 (0.48) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| Trifluoroacetic Acid SCHEMBL3964522 | 0.91 | FGFR1 (0.47) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| SCHEMBL3966593 | 0.88 | FGFR1 (0.46) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| Trifluoroacetic Acid SCHEMBL3966818 | 0.87 | FGFR1 (0.50) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| Trifluoroacetic Acid SCHEMBL3964521 | 0.86 | FGFR1 (0.42) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| Trifluoroacetic Acid SCHEMBL3965344 | 0.84 | FGFR1 (0.45) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| Trifluoroacetic Acid SCHEMBL3963232 | 0.82 | FGFR1 (0.46) | FGFR1FGFR2FGFR4FGFR3EGFR | |
| SCHEMBL3964101 | 0.79 | FGFR1 (0.46) | FGFR1FGFR2FGFR4FGFR3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |