Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 7/20 | 0.42 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883519 | 0.89 | PDGFRB (0.45) | PDGFRBKDRJAK3LRRK2PDPK1 | |
| SCHEMBL3969605 | 0.86 | JAK3 (0.39) | JAK3BTKLRRK2PDPK1 | |
| SCHEMBL13883524 | 0.80 | TTK (0.49) | PDGFRBKDRJAK3BTKLRRK2 | |
| SCHEMBL13883574 | 0.79 | PDGFRB (0.42) | PDGFRBKDRSYKLRRK2NAMPT | |
| SCHEMBL13883717 | 0.77 | KDR (0.46) | PDGFRBKDRSYKLRRK2PDPK1 | |
| SCHEMBL13883706 | 0.77 | JAK2 (0.45) | PDGFRBJAK3BTKLRRK2PDPK1 | |
| SCHEMBL13883730 | 0.76 | HRH3 (0.47) | JAK3BTKLRRK2PDPK1 | |
| SCHEMBL13883719 | 0.76 | JAK2 (0.43) | JAK3BTKLRRK2PDPK1 | |
| SCHEMBL13883687 | 0.76 | KDR (0.44) | PDGFRBKDRJAK3BTKLRRK2 | |
| SCHEMBL13883705 | 0.76 | JAK2 (0.43) | PDGFRBKDRJAK3BTKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |