Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.45 |
| ▸ | CDK9 | P50750 | 8/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 4/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.42 |
| ▸ | CDK7 | P50613 | 4/20 | 0.42 |
| ▸ | CCNH | P51946 | 4/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883500 | 0.92 | JAK2 (0.46) | CDK2CCNA2CCNT1CDK9TTK | |
| SCHEMBL13883523 | 0.92 | TTK (0.53) | TTKJAK2BRD4EGFRJAK1 | |
| SCHEMBL13883690 | 0.91 | JAK2 (0.43) | CDK2CCNA2CCNT1CDK9TTK | |
| SCHEMBL13883697 | 0.90 | JAK2 (0.41) | CDK2CCNA2CCNT1CDK9TTK | |
| SCHEMBL13883495 | 0.90 | TTK (0.42) | CDK2CCNA2CCNT1CDK9TTK | |
| SCHEMBL13883685 | 0.90 | JAK2 (0.44) | CDK2CCNA2TTKJAK2BRD4 | |
| SCHEMBL13883692 | 0.90 | JAK2 (0.41) | CDK2CCNA2CCNT1CDK9TTK | |
| SCHEMBL4084023 | 0.89 | TTK (0.49) | CDK2CCNA2CCNT1CDK9TTK | |
| SCHEMBL13883687 | 0.89 | KDR (0.44) | CDK2CCNA2CCNT1CDK9TTK | |
| SCHEMBL3964197 | 0.88 | JAK2 (0.40) | CDK2CCNA2CCNT1CDK9TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |